ABSTRACT
<p><b>AIM</b>To investigate the changes of the spermatozoa ultrastructures before and after renal transplantation in uremic patients.</p><p><b>METHODS</b>The sperm of five uremic patients before and after transplantation and four healthy volunteers were collected and examined by scanning electron microscopy.</p><p><b>RESULTS</b>Abnormal spermatozoa were found in patients pre-transplantation; abnormalities included deletion of the acrosome, absence of the postacrosomal and postnuclear ring, dumbbell-like changes of the head, tail curling, and absence of the mitochondrial sheath in the mid-segment. After renal transplantation, most of the spermatozoa became normal.</p><p><b>CONCLUSION</b>There are many abnormalities with regard to the appearance and structure of the head, acrosome, mitochondria and tail of the spermatozoa in uremic patients. The majority of the spermatozoa returned to normal after renal transplantation, but a few still presented some abnormalities possibly relating to the administration of immunosuppressants.</p>
Subject(s)
Adult , Humans , Male , Acrosome , Pathology , Case-Control Studies , Kidney Failure, Chronic , Kidney Transplantation , Microscopy, Electron , Renal Dialysis , Sperm Head , Pathology , Sperm Tail , Pathology , Spermatozoa , PathologyABSTRACT
<p><b>OBJECTIVES</b>To investigate sexual function before and after kidney transplantation in patients with chronic nephrosis.</p><p><b>METHODS</b>Eighty-six male patients were divided into 3 age groups: young-age group (Group A), middle-age group(Group B) and elder-age group(Group C). Sexual function, including potency, frequency and satisfaction of intercourse before and after the sickening, and after transplantation, were recorded in each group.</p><p><b>RESULTS</b>All the patients were potent before suffering from nephrosis. The proportion of patients who were potent after catching the disease in Group A, B and C was 28.6%, 13.8% and 9.1%, respectively. Notably, the proportion of patients remaining potent after transplantation in Group A, B and C was 88.6%, 75.9% and 63.6%, respectively.</p><p><b>CONCLUSIONS</b>Quality of sexual life is significantly improved after kidney transplantation. The younger the patients, the better the improvement.</p>
Subject(s)
Adult , Humans , Male , Middle Aged , Kidney Transplantation , Quality of Life , Sexual Behavior , Surveys and QuestionnairesABSTRACT
<p><b>OBJECTIVES</b>To evaluate the effects of different dosages of cyclosporine A (CsA) on the main semen parameters and sperm morphology of the patients after renal transplantation.</p><p><b>METHODS</b>The semen of 18 patients after renal transplantation treated with different dosages of CsA was analyzed and the semen parameters and sperm morphology were compared with those of 12 normal volunteers.</p><p><b>RESULTS</b>There was not significant difference between the main parameters of the patients treated with 1.5-3.0 mg.Kg-1.d-1 of CsA and 3.1-5.5 mg.Kg-1.d-1 of CsA and those of the volunteers (P > 0.05), but the rate of normal sperm morphology was significantly different between the two groups(P < 0.05).</p><p><b>CONCLUSIONS</b>Different therapeutic dosages of CsA did not have any effect on most of the semen parameters of the patients after renal transplantation, but did affect the sperm morphology.</p>